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Kratom in the fight against free radicals and diseases related to them

The human organismiscomposed of cells that need energy to perform their vital functions normally. They obtainit during cellularrespiration, anoxidativeprocess in whichglucose and fattyacids consume oxygen and produce ATP (adenosinetriphosphate) and energy. But, thisprocessisnotperfect and othermolecules are alsoproduced, amongthemthe so-called free radicals. Thesesubstances are atomsormoleculesthathaveoneor more unpairedelectrons in theirorbitals, thisbeing a chemicallyveryunstablesituationsincetheloneelectron looks for a pairto complete the orbital, so theseatomsormoleculessubtractanelectronfromanymoleculeneighbor, oxidizesthismolecule, alteringitsstructure, damagingit and convertingitintoanother free radical, thusgenerating a chainreaction. Free radicalsthusdeterioratethecellsuntilthey are destroyed.

Free radicals are naturallygeneratedbyourbody and to a certainextent are notalwaysharmful. Itshighly reactive and destructivenatureisusedbythebody'simmunesystem. Forexample, certainwhitebloodcells, calledphagocytes, can wrapforeignparticles, such as bacteria, thensealthem and release free radicalstodestroythem.

Ourbodies can manage a certainlevel of free radicals, butiftoomany are formed, they can seriouslydamagethebody's normal defenses. Free radicals can be increasedbyfactorsrelatedtolifestylesuch as stress, poordiet, air and waterpollution, tobacco, etc.
Thebodydefendsitselfagainsttheharmfulaction of free radicalsthroughantioxidantsystems, so that free radicals and antioxidants are balanced and damageisminimized.

Antioxidants are compoundsthattraporneutralize free radicals, givingthemanelectronwhichdeactivatesthem and neutralizesthechainprocessthroughwhichthedamagethey produce ispropagated. Theseantioxidants do nottransforminto free radicalsduetothegreatmobility of theirelectrons, orifthey do, they are of lowreactivity.

Whenthe balance between free radicals and antioxidantsislost in favor of theformer, oxidative stress occurs, whichisassociatedwiththedevelopment of numerousdiseases, such as cancer, arteriosclerosis, inflammatoryprocesses, cataracts, Parkinson'sdisease, etc. And in addition, thebiologicalprocess of agingaccelerates in directrelationwithoxidative stress.

Antioxidants can be endogenous, producedbyourbody, orexogenous, found in food.

Amongtheantioxidantsthatenterin ourbodythroughfoodwe can highlighttheantioxidantvitamins, carotenoids and polyphenols, which are animportantgroup of compoundspresent in fruits and vegetables and drinkssuch as tea and wine.

In theestimation of thecomposition of thekratomextract (mitragynaspeciosa) a tree of thecoffeefamily, thephytochemicalsfound in variousparts of thetreeincludeflavonoids, saponins, terpenoids and polyphenolsamongotherantioxidants. Thesehaveextensiveliteratureassociatedwiththeirantioxidantactionbutwhat has beenrecentlytested in a studyistheantioxidantvalue and antiproliferativeefficacy of mitragynine (MTG) one of thepredominantalkaloidsresponsiblefortheeffects of kratom (Goh TB, KohRY ,Mordi MN, Mansor SM. '' Antioxidantvalue and antiproliferativeefficacy of mitragynine and a silanereducedanalogue ''.)

Thestudywascarriedoutby DPPH essaysthatmakes use of thestable radical DPPH (2,2-Diphenyl-1-picrylhydrazyl), which has a strongpurple color that can be measuredspectrophotometrically.

Thefindings in thevalues of themitragynineanaloguesmakeitappear as a new source of antioxidantstopreventtheprogress of variousdiseasesinducedbyoxidative stress, includingcancer. In addition, thisstudyjustifiestheefficacy of theanaloguesrelatedtomitragynine as possible anti-cancer and chemopreventivedrugs.


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